Complete sequence analysis of mitochondrial DNA of aplastic anemia patients.

@article{Cui2012CompleteSA,
  title={Complete sequence analysis of mitochondrial DNA of aplastic anemia patients.},
  author={Xing Cui and F Liu and Junhui Wang and Wei Jia Zhang and Jian-yao Wang and Kai Liu and Shao Yuan Cui and J Zhang and Ray Ruian Xu},
  journal={Genetics and molecular research : GMR},
  year={2012},
  volume={11 3},
  pages={2130-7}
}
This study was primarily undertaken to test the hypothesis that mitochondrial DNA (mtDNA) mutations may be associated with aplastic anemia (AA). We analyzed mtDNA sequences from 15 patients with AA. The samples were obtained from bone marrow, and patients' oral epithelial cells were collected for normal tissue comparison. Total DNA was amplified by PCR after extraction, and these segments were then sent for sequencing. The results were compared with those of oral epithelial tissues as well as… CONTINUE READING