Complete replacement of the mitochondrial genotype in a Bos indicus calf reconstructed by nuclear transfer to a Bos taurus oocyte.

@article{Meirelles2001CompleteRO,
  title={Complete replacement of the mitochondrial genotype in a Bos indicus calf reconstructed by nuclear transfer to a Bos taurus oocyte.},
  author={Fl{\'a}vio Vieira Meirelles and Vilceu Bordignon and Yuichiro Watanabe and Masao Watanabe and Alain Dayan and Raysildo Barbosa L{\^o}bo and Joaquim Mansano Garcia and Lawrence Charles Smith},
  journal={Genetics},
  year={2001},
  volume={158 1},
  pages={351-6}
}
Due to the exclusively maternal inheritance of mitochondria, mitochondrial genotypes can be coupled to a particular nuclear genotype by continuous mating of founder females and their female offspring to males of the desired nuclear genotype. However, backcrossing is a gradual procedure that, apart from being lengthy, cannot ascertain that genetic and epigenetic changes will modify the original nuclear genotype. Animal cloning by nuclear transfer using host ooplasm carrying polymorphic… CONTINUE READING

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