Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells.

@article{KIPJ1996CompleteRO,
  title={Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells.},
  author={Hidari KIPJ and Sohsuke Ichikawa and Tetsuo Fujita and Hisako Sakiyama and Yoshio Hirabayashi},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 24},
  pages={14636-41}
}
GM-95, a mutant cell line derived from mouse melanoma MEB-4 cells, is deficient in glycosphingolipids (GSLs) due to the lack of ceramide glucosyltransferase-1 activity (Ichikawa, S., Nakajo, N., Sakiyama, H., and Hirabayashi, Y. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2703-2707). In this study, we examined the involvement of the complex sphingolipids in cell to substratum adhesion. Immunofluorescent and chemical analyses revealed that the complex sphingolipids were significantly concentrated… CONTINUE READING

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