Complete regression of MX-1 human breast carcinoma xenografts after targeted chemotherapy with a cytotoxic analog of luteinizing hormone-releasing hormone, AN-207.

@article{Kahn1999CompleteRO,
  title={Complete regression of MX-1 human breast carcinoma xenografts after targeted chemotherapy with a cytotoxic analog of luteinizing hormone-releasing hormone, AN-207.},
  author={Zsuzsanna Kah{\'a}n and Attila Nagy and Andrew V Schally and G{\'a}bor Halmos and Jose M Arencibia and Kate Groot},
  journal={Cancer},
  year={1999},
  volume={85 12},
  pages={2608-15}
}
BACKGROUND Receptors for luteinizing hormone-releasing hormone (LH-RH) are found in about 50% of human breast carcinomas. A highly potent cytotoxic agent, 2-pyrrolinodoxorubicin (AN-201), was linked to the agonist [D-Lys6]LH-RH to form a cytotoxic LH-RH analog, AN-207, that can be targeted to LH-RH receptors on breast carcinomas. METHODS Nude mice bearing… CONTINUE READING