Resection of liver metastasis has led to improved survival in selected patients with colorectal cancer. Neoadjuvant chemotherapy in this setting has many advantages. Positron emission tomography scan (PET) is useful in monitoring the response of the liver metastases to chemotherapy. Neoadjuvant chemotherapy can cause a complete response of the liver metastasis in some patients. We report a complete radiological and metabolic response of a liver metastasis following neoadjuvant chemotherapy and discuss the therapeutic implications and options in such a situation.