Complete protein structure determination using backbone residual dipolar couplings and sidechain rotamer prediction

@article{Andrec2002CompletePS,
  title={Complete protein structure determination using backbone residual dipolar couplings and sidechain rotamer prediction},
  author={Michael Andrec and Yuichi Harano and Matthew P. Jacobson and Richard A. Friesner and Ronald M. Levy},
  journal={Journal of Structural and Functional Genomics},
  year={2002},
  volume={2},
  pages={103-111}
}
Residual dipolar couplings provide significant structural information for proteins in the solution state, which makes them attractive for the rapid determination of protein structures. While dipolar couplings contain inherent structural ambiguities, these can be reduced via an overlap similarity measure that insists that protein fragments assigned to overlapping regions of the sequence must have self-consistent structures. This allows us to determine a backbone fold (including the correct Cα–C… CONTINUE READING

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