Complete primary structure of a scallop striated muscle myosin heavy chain. Sequence comparison with other heavy chains reveals regions that might be critical for regulation.

@article{Nyitray1991CompletePS,
  title={Complete primary structure of a scallop striated muscle myosin heavy chain. Sequence comparison with other heavy chains reveals regions that might be critical for regulation.},
  author={L{\'a}szl{\'o} Nyitray and Elizabeth B. Goodwin and Andrew G. Szent-Gy{\"o}rgyi},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 28},
  pages={18469-76}
}
We have determined the primary structure of the myosin heavy chain (MHC) of the striated adductor muscle of the scallop Aequipecten irradians by cloning and sequencing its cDNA. It is the first heavy chain sequence obtained in a directly Ca(2+)-regulated myosin. The 1938-amino acid sequence has an overall structure similar to other MHCs. The subfragment-1 region of the scallop MHC has a 59-62% sequence identity with sarcomeric and a 52-53% identity with nonsarcomeric (smooth and metazoan… CONTINUE READING