Complete pathological responses in locally advanced rectal cancer after preoperative IMRT and integrated-boost chemoradiation

@article{HernandoRequejo2014CompletePR,
  title={Complete pathological responses in locally advanced rectal cancer after preoperative IMRT and integrated-boost chemoradiation},
  author={Ovidio Hernando-Requejo and Mercedes Lopez and Antonio Cubillo and Almudena Rodriguez and Raquel Ci{\'e}rvide and Jeannette Valero and Emilio S{\'a}nchez and Mariola Garc{\'i}a-Aranda and Jesus Diez Rodr{\'i}guez and Guillermo Potdevin and Carmen Rubio},
  journal={Strahlentherapie und Onkologie},
  year={2014},
  volume={190},
  pages={515-520}
}
To analyze the efficacy and safety of a new preoperative intensity-modulated radiotherapy (IMRT) and integrated-boost chemoradiation scheme. In all, 74 patients were treated with IMRT and concurrent standard dose capecitabine. The dose of the planning target volume (PTV) encompassing the tumor, mesorectum, and pelvic lymph nodes was 46 Gy in 23 fractions; the boost PTV, at a dose of 57.5 Gy in 23 fractions, included the macroscopic primary tumor and pathological lymph nodes. The patients… CONTINUE READING