Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

@article{Capon1983CompleteNS,
  title={Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue},
  author={Daniel Jeffrey Capon and Ellson Y. Chen and Arthur D. Levinson and P. H. Seeburg and David V. Goeddel},
  journal={Nature},
  year={1983},
  volume={302},
  pages={33-37}
}
DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least four exons, and that only a single point mutation residing within the first exon distinguishes the coding region of both alleles of the normal gene from their activated counterpart. Both versions o f the gene encode a protein which is predicted to differ from the corresponding viral gene product at… CONTINUE READING
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