Complete nucleotide sequences of functional clones of the AIDS virus.

  title={Complete nucleotide sequences of functional clones of the AIDS virus.},
  author={L. S. Ratner and Amanda G Fisher and Linda L. Jagodzinski and Hiroaki Mitsuya and Ruey-Ming Liou and Robert C. Gallo and Flossie Wong-Staal},
  journal={AIDS research and human retroviruses},
  volume={3 1},
To examine the mechanism of lymphocytotoxicity induced by human T-lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV), an in vitro model has been developed. Introduction of an HTLV-III/LAV proviral clone, HXB2, into normal lymphocytes results in the production of virions and cell death. The complete nucleotide sequence of the proviral form of HXB2 has now been determined. Its structure is quite similar to that previously determined for HTLV-III/LAV clones whose… CONTINUE READING
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