Complete nucleotide sequence of the AIDS virus, HTLV-III

@article{Ratner1985CompleteNS,
  title={Complete nucleotide sequence of the AIDS virus, HTLV-III},
  author={Lee Ratner and William A. Haseltine and Roberto Patarca and Kenneth J. Livak and Bruno Starcich and Steven F. Josephs and Ellen R. Doran and Jan Antoni Rafalski and Erik A. Whitehorn and Kirk Baumeister and Lucinda A. Ivanoff and Stephen Robert Petteway and Mark L. Pearson and J. A. Lautenberger and Takis S. Papas and John Ghrayeb and Nancy T. Chang and Robert C. Gallo and Flossie Wong-Staal},
  journal={Nature},
  year={1985},
  volume={313},
  pages={277-284}
}
The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II. 
Molecular cloning of the closed circular provirus of human T cell leukaemia virus type I: a new open reading frame in the gag-pol region.
TLDR
It is considered that this open reading frame codes for the virus-encoded protease, on the basis of the homology of the predicted amino acid sequence with those of previously identified retrovirus proteases.
Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.
TLDR
The genome of the human T-lymphotropic virus type III (HTLV-III/LAV) has the potential to encode at least three polypeptides in addition to those encoded by the gag, pol, and env genes, and in this study the product of the sor (short open reading frame) region was found to be a protein with a molecular weight of 23,000.
Human immunodeficiency virus: the eighth gene.
TLDR
It is demonstrated that there is an eighth gene which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people.
The sequence of human immunodeficiency virus type 2 circle junction suggests that integration protein cleaves the ends of linear DNA asymmetrically
The sequence of the human immunodeficiency virus type 2 circle junction was determined. The most common sequence found between the conserved CA and TG dinucleotides at the ends of the integrated
Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity
TLDR
A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.
The genome organization of STLV-3 is similar to that of the AIDS virus except for a truncated transmembrane protein
Nucleotide sequence analysis of the 3' portion of the genome of simian T-lymphotropic virus type 3 from African green monkeys (STLV-3agm) reveals that it has the same general genome structure as the
Expression of reverse transcriptase activity of human T-lymphotropic virus type III (HTLV-III/LAV) in Escherichia coli
The pol gene from a biologically active clone of the human T-cell lymphotropic virus type III provirus was inserted into a bacterial expression vector. The resulting gene fusion induced the formation
CHARACTERIZATION OF THE ENV GENE AND OF TWO NOVEL CODING REGIONS OF THE HUMAN SPUMARETROVIRUS
Recombinant cJones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced
The trans-activator gene of HTLV-III is essential for virus replication
TLDR
It is shown that derivatives of a biologically competent molecular clone of HTLV-III, in which the tat-Ill gene is deleted or the normal splicing abrogated, failed to produce or expressed unusually low levels of virus, respectively, when transfected into T-cell cultures.
A novel gene of HIV-1, vpu, and its 16-kilodalton product.
TLDR
The data suggest that the vpu gene product is required for efficient virus replication and may have a role in assembly or maturation of progeny virions.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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