Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer.

@article{Troudi2008CompleteMS,
  title={Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer.},
  author={Wafa Troudi and Nancy Uhrhammer and Khaled Ben Romdhane and Catherine Sibille and Mohamed Ben Amor and Houssein Khodjet el Khil and T Jalabert and Wijden Mahfoudh and Lotfi Chouchane and Farhat Ben Ayed and Y. J. Bignon and Amel Ben Ammar Elgaaied},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2008},
  volume={4 1},
  pages={11-8}
}
Breast cancer, the most commonly diagnosed cancer in women, is the second leading cause of cancer death in women worldwide. To investigate the contribution of BRCA1 gene mutations to familial breast cancer in Tunisia, 32 unrelated patients who had at least one first degree relative affected with breast and/or ovarian cancer were analysed. BRCA1 mutation analysis was performed by DNA sequencing of all BRCA1 exons. We identified four different BRCA1 frameshift mutations: c.4041delAG, c.2551delG… CONTINUE READING