Complete multipoint sib-pair analysis of qualitative and quantitative traits.

  title={Complete multipoint sib-pair analysis of qualitative and quantitative traits.},
  author={Leonid Kruglyak and Eric S. Lander},
  journal={American journal of human genetics},
  volume={57 2},
Sib-pair analysis is an increasingly important tool for genetic dissection of complex traits. Current methods for sib-pair analysis are primarily based on studying individual genetic markers one at a time and thus fail to use the full inheritance information provided by multipoint linkage analysis. In this paper, we describe how to extract the complete multipoint inheritance information for each sib pair. We then describe methods that use this information to map loci affecting traits, thereby… CONTINUE READING
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