Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with Type I diabetes mellitus

@article{Nolse2000CompleteMS,
  title={Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with Type I diabetes mellitus},
  author={Runa L. Nols\oe and Ole Peter Kristiansen and K. Sangthongpitag and Z. M. Larsen and Jesper Johannesen and A. E. Karlsen and Flemming Pociot and J\orn Nerup and Charles F Verge and Thomas Mandrup-Poulsen},
  journal={Diabetologia},
  year={2000},
  volume={43},
  pages={800-808}
}
Aims/hypothesis. The human Fas gene (FAS) on chromosome 10q24.1 encoding a cell surface receptor involved in apoptosis was evaluated as a candidate susceptibility gene for Type I (insulin-dependent) diabetes mellitus. Apoptosis mediated by Fas is important in maintaining peripheral self-tolerance and in down-regulating the immune response and could have a role in immune-mediated beta-cell destruction.¶Methods. We did a molecular scan of the entire human FAS (promoter, exons 1–9 including exon… CONTINUE READING

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