Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.

@article{Schmitz2007CompleteLO,
  title={Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.},
  author={Martine Schmitz and G{\'e}rard Grignard and Christiane M Margue and Walter Dippel and Catherine Capesius and Jo{\"e}l Mossong and Michel Nathan and Sandro Giacchi and Ren{\'e} Scheiden and Nelly Kieffer},
  journal={International journal of cancer},
  year={2007},
  volume={120 6},
  pages={1284-92}
}
The EGF/IGF growth factors are potent mitogens that regulate cell proliferation and cell survival and are involved in prostate cancer development. Using laser microdissection technology and real-time PCR, together with immunohistochemistry, we have explored the growth factor and integrin dependent PI3-kinase/PTEN/Akt signalling pathway in prostate cell lines and tumour samples by analysing EGF-R, IGF1-R, ILK, beta3 integrin, PTEN and p-Akt protein expression. We provide evidence that loss of… CONTINUE READING