Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.

@article{Karray2004CompleteLO,
  title={Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.},
  author={Saoussen Karray and Chantal Kress and Sylvain Cuvellier and Catherine Hue-Beauvais and Diane Damotte and Charles Babinet and Matthieu L{\'e}vi-Strauss},
  journal={Journal of immunology},
  year={2004},
  volume={172 4},
  pages={2118-25}
}
To investigate the in vivo function of Fas ligand (FasL), we produced a mouse strain with a FasL gene flanked by loxP sequences. Mice with homozygous floxed FasL gene showed no obvious abnormalities. However, germline deletion of the FasL gene, obtained after mating with mice expressing ubiquitous Cre recombinase, resulted in an unexpectedly severe phenotype. FasL(-/-) mice exhibited an extreme splenomegaly and lymphadenopathy associated with lymphocytic infiltration into multiple organs and… CONTINUE READING
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