Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

@article{Kim2003CompleteIA,
  title={Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).},
  author={N C Kim and Tyler N Graf and Charles M Sparacino and Mansukh C. Wani and Monroe E. Wall},
  journal={Organic & biomolecular chemistry},
  year={2003},
  volume={1 10},
  pages={1684-9}
}
Complete separation, isolation, and structural characterization of four diastereoisomeric flavonolignans, silybins A (1) and B (2), and isosilybins A (3) and B (4) from the seeds of milk thistle (Silybum marianum) were achieved for the first time using a preparative reversed-phase HPLC method. In addition, three other flavonolignans, silychristin (5) isosilychristin (6) and silydianin (7), and a flavonoid, taxifolin (8) were isolated. Structures, including absolute stereochemistries of 1-4… CONTINUE READING

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