Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44.

@article{Hidalgo2007CompleteIO,
  title={Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44.},
  author={Andr{\'e}s Hidalgo and Anna Julie Peired and Martin K. Wild and Dietmar Vestweber and Paul S Frenette},
  journal={Immunity},
  year={2007},
  volume={26 4},
  pages={477-489}
}
The selectins and their ligands are required for leukocyte extravasation during inflammation. Several glycoproteins have been suggested to bind to E-selectin in vitro, but the complete identification of its physiological ligands has remained elusive. Here, we showed that E-selectin ligand-1 (ESL-1), P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 encompassed all endothelial-selectin ligand activity on neutrophils by using gene- and RNA-targeted loss of function. PSGL-1 played a major role… CONTINUE READING
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egress from bone marrow

  • Y. Katayama, A. Hidalgo, J. Chang, A. Peired, P. S. Frenette
  • 2005
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