Complete high-density lipoproteins in nanoparticle corona.

@article{Hellstrand2009CompleteHL,
  title={Complete high-density lipoproteins in nanoparticle corona.},
  author={Erik Hellstrand and Iseult Lynch and Astra Andersson and Torbj{\"o}rn Drakenberg and Bj{\"o}rn Dahlb{\"a}ck and Kenneth A. Dawson and Sara Linse and Tommy Cedervall},
  journal={The FEBS journal},
  year={2009},
  volume={276 12},
  pages={3372-81}
}
In a biological environment, nanoparticles immediately become covered by an evolving corona of biomolecules, which gives a biological identity to the nanoparticle and determines its biological impact and fate. Previous efforts at describing the corona have concerned only its protein content. Here, for the first time, we show, using size exclusion chromatography, NMR, and pull-down experiments, that copolymer nanoparticles bind cholesterol, triglycerides and phospholipids from human plasma, and… CONTINUE READING