Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate.

@article{Delanian2002CompleteHO,
  title={Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate.},
  author={Sylvie Delanian and J. L. Lefaix},
  journal={The British journal of radiology},
  year={2002},
  volume={75 893},
  pages={467-9}
}
Osteoradionecrosis (ORN) is a late terminal sequela of irradiation that does not resolve spontaneously. In a preliminary study, a combination of pentoxifylline (PTX), tocopherol (Vit-E) and clodonate has been shown to be of clinical benefit with more than 50% regression of progressive ORN observed at 6 months in 12 patients. A 68-year-old woman presenting with severe exteriorized osteoradionecrosis had received radiotherapy for breast cancer 29 years previously. She had palpable breast fibrosis… CONTINUE READING