Complete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients

  title={Complete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients},
  author={İnci Çelik and Ersin Karataylı and Emrah Çevik and S. G{\"o}kçe Kabakçı and Senem Ceren Karatayli and Bedia Dinç and Kubilay Çınar and Kendal Yalcin and Ramazan Idilman and Cihan Yurdaydın and Abdurrahman Mithat Bozdayi},
  journal={Archives of Virology},
Hepatitis delta virus (HDV) is a subviral agent of hepatitis B virus (HBV), and its life cycle is dependent on HBV. It is commonly accepted that HDV has eight distinct genotypes. In this study, the complete nucleotide sequences of HDV genomes isolated from nine Turkish patients were obtained by RT-PCR using two pairs of primers that cover the entire HDV genome. PCR products were sequenced directly. The results showed that these 9 isolates were approximately 1680 base pairs in length and… 
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The prevalence of intergenotypic recombination between HDV genotypes 1 and 2 in a Vietnamese HBsAg‐positive patient is demonstrated and a newly identified recombinant of HDVgenotype 1 and HDV 2 is reported.
Distribution of Hepatitis Delta Virus Genotypes in Mashhad, Northeast Iran
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Clade homogeneity and low rate of delta virus despite hyperendemicity of hepatitis B virus in Ethiopia
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Recombinant identification, molecular classification and proposed reference genomes for hepatitis delta virus
A large set of HDV full‐length genome sequences are retrieved and analysed and an updated classification system for HDV is established when recombinants were excluded, and the global distribution of different genotypes and subtypes is mapped.
Different evolutionary dynamics of hepatitis B virus genotypes A and D, and hepatitis D virus genotypes 1 and 2 in an endemic area of Yakutia, Russia
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The overall significant prevalence of HDV (6.5%) mandates HDV RNA testing for all coinfected patients and the lack of effective anti-HDV therapy, necessitates strict clinical surveillance especially in patients with higher HDV viral loads and increased viral evolution.


Hepatitis delta virus (HDV) genotypes in patients with chronic hepatitis: molecular epidemiology of HDV in Turkey.
The predominance of hepatitis delta virus genotype I among chronically infected Italian patients
It is concluded that in Italy, where HDV infection has been endemic, the overwhelmingly predominant genotype of HDV is genotype I, and this genotype appeared to be associated with a broad spectrum of chronic disease.
Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela.
It was concluded that the serious delta hepatitis outbreaks characterized epidemiologically in the Yucpa Amerindians were caused by HDV genotype III isolates that were related to HDV Genotype III isolate from other regions of South America.
Molecular epidemiology of hepatitis B, C and D viruses in Turkish patients
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A genotype of hepatitis D virus that occurs in northern South America.
The association of a particular genotype with the severe form oftype D hepatitis that occurs in northern South America supports the hypothesis that HDV genetic factors are important determinants in the pathogenesis of type D hepatitis.
Editing on the genomic RNA of human hepatitis delta virus
A sensitive assay involving the polymerase chain reaction was developed to monitor changes on HDV RNA sequences as they occurred in transfected cells and found that the substrate for the sequence change was the viral genomic RNA rather than the antigenomic RNA.
Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead
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The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus.
Though the small HDAg is important for viral replication and is incorporated into the virus, the small-form delta antigen by itself is insufficient for virion formation, indicating a crucial role of the large HDAg in HDV assembly.
Structural requirements for RNA editing in hepatitis delta virus: evidence for a uridine-to-cytidine editing mechanism.
Comparisons of mutations that differentiate between base pairing in genomic and antigenomic RNAs indicate that the genomic strand of HDV is the actual editing substrate, which concludes that the virus uses a uridine to cytidine editing mechanism, which is provided by the host cell.
Structure, sequence and expression of the hepatitis delta (delta) viral genome.
Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with