Complete genome sequence of the myxobacterium Sorangium cellulosum

@article{Schneiker2007CompleteGS,
  title={Complete genome sequence of the myxobacterium Sorangium cellulosum},
  author={Susanne Schneiker and Olena Perlova and Olaf Kaiser and Klaus Gerth and Aysel Alici and Matthias Altmeyer and Daniela Bartels and Thomas Bekel and Stefan Beyer and Edna Bode and Helge B. Bode and Christoph Bolten and Jomuna V. Choudhuri and Sabrina Do{\ss} and Yasser A. Elnakady and Bettina Frank and Lars Gaigalat and Alexander Goesmann and Carolin Groeger and Frank Gross and Lars Jelsbak and Lotte Jelsbak and J{\"o}rn Kalinowski and Carsten Kegler and Tina Knauber and Sebastian G. A. Konietzny and Maren Kopp and Lutz Krause and Daniel Krug and Bukhard Linke and Taifo Mahmud and Rosa Mart{\'i}nez-Arias and Alice Mchardy and Michelle Merai and Folker Meyer and Sascha Mormann and Jos{\'e} Mu{\~n}oz-Dorado and Juana P{\'e}rez and Silke Pradella and Shwan Rachid and G{\"u}nter Raddatz and Frank Rosenau and Christian R{\"u}ckert and Florenz Sasse and Maren Scharfe and Stephan C. Schuster and Garret Suen and Anke Treuner-Lange and Gregory J. Velicer and Frank-J{\"o}rg Vorh{\"o}lter and Kira J. Weissman and Roy D. Welch and Silke C Wenzel and David E. Whitworth and Susanne Wilhelm and Christoph Wittmann and Helmut Bl{\"o}cker and Alfred P{\"u}hler and Rolf M{\"u}ller},
  journal={Nature Biotechnology},
  year={2007},
  volume={25},
  pages={1281-1289}
}
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the… 
Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu
TLDR
The comparative transcriptomics approach, which detected 90.7% of the total CDSs, not only demonstrates complex expression patterns under varying environmental conditions but also suggests an alkaline-improved pathway of the insertion and duplication, which has been genetically testified, in this strain.
Complete genome sequence of Haliangium ochraceum type strain (SMP-2T)
TLDR
The features of this organism are described, together with the complete genome sequence, and annotation, and the 9,446,314 bp long single replicon genome with its 6,898 protein-coding and 53 RNA genes is part of the GenomicEncyclopedia ofBacteria andArchaea project.
Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis
TLDR
Analysis revealed an enlarged set of tRNA genes, along with reduced pressure on preferred codon usage compared to that of other bacterial genomes, and extensive genetic information duplication and broad application of eukaryotic-type signal transduction systems in this 11.3-Mbp prokaryotic genome.
Origins of Replication in Sorangium cellulosum and Microcystis aeruginosa
  • F. Gao, Chun-Ting Zhang
  • Biology, Engineering
    DNA research : an international journal for rapid publication of reports on genes and genomes
  • 2008
TLDR
Using Ori-Finder, a recently developed computer program, in both genomes, candidate oriC regions that have almost all sequence hallmarks of bacterial oriCs are identified, such as asymmetrical nucleotide distributions, being adjacent to the dnaN gene, and containing DnaA boxes and repeat elements.
Genetic Engineering of Myxobacterial Natural Product Biosynthetic Genes
TLDR
The heterologous expression of the epothilone gene cluster in M. xanthus provided the opportunity for making novel analogs and understanding novel enzyme mechanisms, and led the way for combinatorial biosynthesis of novel epothILone analogs.
Complete genome sequence and identification of polyunsaturated fatty acid biosynthesis genes of the myxobacterium Minicystis rosea DSM 24000T
TLDR
The complete genome sequence of M. rosea is described, comparative genomic analysis is used to explore the putative reasons for its large genome size, and the secondary metabolite potential is explored, including the biosynthesis of polyunsaturated fatty acids.
The Phosphatomes of the Multicellular Myxobacteria Myxococcus xanthus and Sorangium cellulosum in Comparison with Other Prokaryotic Genomes
TLDR
There has been a greater expansion of ELKs than PPs in multicellular myxobacteria, and the degree of co-organization between kinase and phosphatase genes is extremely low in these myxOBacterial genomes.
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism
TLDR
The genomic information of A. mediterranei demonstrates a metabolic network orchestrated not only for extensive utilization of various carbon sources and inorganic nitrogen compounds but also for effective funneling of metabolic intermediates into the secondary antibiotic synthesis process under the control of a seemingly complex regulatory mechanism.
...
...

References

SHOWING 1-10 OF 60 REFERENCES
Characterisation, genome size and genetic manipulation of the myxobacterium Sorangium cellulosum So ce56
TLDR
S. cellulosum So ce56 was phenotypically and genotypically analysed in order to evaluate whether this strain can be used in a comprehensive genome project as a representative of the secondary metabolite-producing myxobacteria, and was found to have various advantageous features.
Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56
TLDR
It is shown that transcription of the chivosazol biosynthetic genes (chiA–chiF) is directly controlled by this protein, and ChiR serves as a pleiotropic regulator in S. cellulosum, because mutant strains lack the ability to develop into regular fruiting bodies.
Novel Insights into Siderophore Formation in Myxobacteria
TLDR
Biochemical and genetic studies described here further clarify myxochelin biosynthesis and reveal that although the organization of the biosynthetic genes is completely different, the biosynthesis is most probably extremely similar.
19 Sorangium cellulosum
TLDR
The fascinating microorganisms of the genus Sorangium attract more and more attention, because they undergo a complex life cycle, possess the largest bacterial genomes known to date, and show a high potential as producers of biotechnologically important natural products.
Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species
TLDR
Despite the unmistakable organizational similarities between the B. licheniformis and B. subtilis genomes, there are notable differences in the numbers and locations of prophages, transposable elements and a number of extracellular enzymes and secondary metabolic pathway operons that distinguish these species.
Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads
TLDR
The successful heterologous production of a secondary metabolite using a gene not expressed under administered laboratory conditions provides evidence for the usefulness of the approach to activate suchsecondary metabolite genes for the production of novel metabolites.
Evolution of sensory complexity recorded in a myxobacterial genome
TLDR
It is suggested that gene duplication and divergence were major contributors to genomic expansion from its progenitor, and families of genes encoding the production of secondary metabolites are overrepresented in the genome but may have been received by horizontal gene transfer and are likely to be important for predation.
Eukaryotic-type protein kinases in Streptomyces coelicolor: variations on a common theme.
TLDR
A family portrait of the genes identified in the sequence of the S. coelicolor A3(2) genome is presented, and possible roles of these enzymes in the regulation of cellular processes in streptomycetes are suggested.
...
...