Complete development of mosquito phases of the malaria parasite in vitro.

@article{AlOlayan2002CompleteDO,
  title={Complete development of mosquito phases of the malaria parasite in vitro.},
  author={Ebtesam M. Al-Olayan and Annette L Beetsma and Geoffrey A. Butcher and Robert E Sinden and Hilary Hurd},
  journal={Science},
  year={2002},
  volume={295 5555},
  pages={677-9}
}
Methods for reproducible in vitro development of the mosquito stages of malaria parasites to produce infective sporozoites have been elusive for over 40 years. We have cultured gametocytes of Plasmodium berghei through to infectious sporozoites with efficiencies similar to those recorded in vivo and without the need for salivary gland invasion. Oocysts developed extracellularly in a system whose essential elements include co-cultured Drosophila S2 cells, basement membrane matrix, and insect… CONTINUE READING

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