Complete characterization of the 3' region of the human and mouse hereditary hemochromatosis HFE gene and detection of novel splicing forms.

@article{Sanchez2001CompleteCO,
  title={Complete characterization of the 3' region of the human and mouse hereditary hemochromatosis HFE gene and detection of novel splicing forms.},
  author={Mayka Sanchez and Miquel Bruguera and J. J. Rodes and Rafael Oliva},
  journal={Blood cells, molecules & diseases},
  year={2001},
  volume={27 1},
  pages={35-43}
}
The human HFE gene was identified in 1996 as the gene whose mutations are responsible for hereditary hemochromatosis in most patients. Expression analysis by Northern blot indicated that the gene was approximately 4.1 kb in length. However, the cDNA reported was only 2716 bp. These results implied that at least 1.4 kb of the mRNA remained to be identified. In the present study, we detected several 3' EST clones while screening the genomic region of the gene in search of potential additional HFE… CONTINUE READING

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