Complete characterization of posttranslational modification sites in the bovine milk protein PP3 by tandem mass spectrometry with electron capture dissociation as the last stage.

@article{Kjeldsen2003CompleteCO,
  title={Complete characterization of posttranslational modification sites in the bovine milk protein PP3 by tandem mass spectrometry with electron capture dissociation as the last stage.},
  author={Frank Kjeldsen and Kim F. Haselmann and Bogdan Budnik and Esben Skipper S{\o}rensen and Roman A. Zubarev},
  journal={Analytical chemistry},
  year={2003},
  volume={75 10},
  pages={
          2355-61
        }
}
A comprehensive approach to protein identification and determination of sites of posttranslational modifications (PTMs) in heavily modified proteins was tested. In this approach, termed "reconstructed molecular mass analysis" (REMMA), the molecular mass distribution of the intact protein is measured first, which reveals the extent and heterogeneity of modifications. Then the protein is digested with one or several enzymes, with peptides separated by reversed-phase HPLC, and analyzed by Fourier… CONTINUE READING

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