Complete blockage of the mevalonate pathway results in male gametophyte lethality

@article{Suzuki2009CompleteBO,
  title={Complete blockage of the mevalonate pathway results in male gametophyte lethality},
  author={Masashi Suzuki and Shoko Nakagawa and Yukiko Kamide and Keiko Kobayashi and Kiyoshi Ohyama and Hiromi Hashinokuchi and Reiko Kiuchi and Kazuki Saito and Toshiya Muranaka and Noriko Nagata},
  journal={Journal of Experimental Botany},
  year={2009},
  volume={60},
  pages={2055 - 2064}
}
Plants have two isoprenoid biosynthetic pathways: the cytosolic mevalonate (MVA) pathway and the plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Since the discovery of the MEP pathway, possible metabolic cross-talk between these pathways has prompted intense research. Although many studies have shown the existence of such cross-talk using feeding experiments, it remains to be determined if native cross-talk, rather than exogenously applied metabolites, can compensate for complete… CONTINUE READING

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