Complete androgen insensitivity: Pathophysiology, diagnosis, and management

  title={Complete androgen insensitivity: Pathophysiology, diagnosis, and management},
  author={J. Imperato-McGinley and W. J. Canovatchel},
  journal={Trends in Endocrinology & Metabolism},
  • J. Imperato-McGinley, W. J. Canovatchel
  • Published 1992
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
  • The syndrome of complete androgen insensitivity is an X-linked inherited disorder resulting in marked inhibition of androgen action. The following case illustrates a subject with complete androgen insensitivity who, despite being a genetic and gonadal male, presents as a phenotypic female with primary amenorrhea, normal breast development, and lack of axillary and pubic hair. The diagnosis, pathophysiology, and management of the condition are discussed, as well as recently identified… CONTINUE READING
    16 Citations
    5alpha-reductase-2 deficiency and complete androgen insensitivity: lessons from nature.
    • 41
    Androgen receptor dysfunction in human androgen insensitivity
    • T. Brown
    • Biology, Medicine
    • Trends in Endocrinology & Metabolism
    • 1995
    • 8
    Perspectives in Pediatric Pathology, Chapter 6. Male Undermasculinization
    • 7


    Androgen insensitivity in man: evidence for genetic heterogeneity.
    • 142
    • PDF
    The syndromes of androgen resistance revisited.
    • 17
    The syndrome of testicular feminization in male pseudohermaphrodites.
    • J. Morris
    • Medicine
    • American journal of obstetrics and gynecology
    • 1953
    • 505