Complete Sequencing of pNDM-HK Encoding NDM-1 Carbapenemase from a Multidrug-Resistant Escherichia coli Strain Isolated in Hong Kong

@inproceedings{Ho2011CompleteSO,
  title={Complete Sequencing of pNDM-HK Encoding NDM-1 Carbapenemase from a Multidrug-Resistant Escherichia coli Strain Isolated in Hong Kong},
  author={Pak-leung Ho and Wai U. Lo and Man Kiu Yeung and Chi Ho Lin and Kin Hung Chow and Irene Ang and Amy Hin Yan Tong and Jessie Yun-Juan Bao and S Y Lok and Janice Yee Chi Lo},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND The emergence of plasmid-mediated carbapenemases, such as NDM-1 in Enterobacteriaceae is a major public health issue. Since they mediate resistance to virtually all β-lactam antibiotics and there is often co-resistance to other antibiotic classes, the therapeutic options for infections caused by these organisms are very limited. METHODOLOGY We characterized the first NDM-1 producing E. coli isolate recovered in Hong Kong. The plasmid encoding the metallo-β-lactamase gene was… CONTINUE READING
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Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTXM-3

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