• DOI:10.1126/SCIENCE.1114016
Corpus ID: 39586368

Complete Replication of Hepatitis C Virus in Cell Culture

@article{Lindenbach2005CompleteRO,
  title={Complete Replication of Hepatitis C Virus in Cell Culture},
  author={B. Lindenbach and M. Evans and A. Syder and B. W{\"o}lk and T. Tellinghuisen and C. C. Liu and T. Maruyama and R. Hynes and D. Burton and J. McKeating and C. Rice},
  journal={Science},
  year={2005},
  volume={309},
  pages={623 - 626}
}

B. Lindenbach, M. Evans, +8 authors C. Rice

Published 2005

Biology, Medicine

Science

Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc). Replication of HCVcc was robust, producing nearly 105 infectious units per milliliter within 48 hours. Virus particles were filterable and neutralized with a monoclonal antibody against the viral… CONTINUE READING

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