Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS.

  title={Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS.},
  author={Hubert Kettenberger and Karim-Jean Armache and Patrick Cramer},
  journal={Molecular cell},
  volume={16 6},
The crystal structure of the complete 12 subunit RNA polymerase (pol) II bound to a transcription bubble and product RNA reveals incoming template and nontemplate DNA, a seven base pair DNA/RNA hybrid, and three nucleotides each of separating DNA and RNA. The complex adopts the posttranslocation state and accommodates a cocrystallized nucleoside triphosphate (NTP) substrate. The NTP binds in the active site pore at a position to interact with a DNA template base. Residues surrounding the NTP… CONTINUE READING
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Architecture of the initiation-competent 12-subunit RNA polymerase II

  • Armache, K.-J, H. Kettenberger, P. Cramer
  • Proc. Natl. Acad. Sci. USA
  • 2003
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Complete RNA polymerhelix domain in general transcription factor E / IIE  . J . Biol . Chem . ase II at 4 . 1 Å resolution : implications for the initiation of transcrip278 , 48267 – 48274 . tion

  • R. D. Kornberg
  • Proc . Natl . Acad . Sci . USA
  • 2003
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