Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes

@article{Gupta2011CompleteKT,
  title={Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes},
  author={P. Gupta and C. Fillmore and G. Jiang and Sagi D. Shapira and Kai Tao and C. Kuperwasser and E. Lander},
  journal={Cell},
  year={2011},
  volume={146},
  pages={568-581}
}
Chromosomes must establish stable biorientation prior to anaphase to achieve faithful segregation during cell division. The detailed process by which chromosomes are bioriented and how biorientation is coordinated with spindle assembly and chromosome congression remain unclear. Here, we provide complete 3D kinetochore-tracking datasets throughout cell division by high-resolution imaging of meiosis I in live mouse oocytes. We show that in acentrosomal oocytes, chromosome congression forms an… Expand
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