Complete Genomes Reveal Signatures of Demographic and Genetic Declines in the Woolly Mammoth
@article{Palkopoulou2015CompleteGR, title={Complete Genomes Reveal Signatures of Demographic and Genetic Declines in the Woolly Mammoth}, author={Eleftheria Palkopoulou and Swapan Mallick and Pontus Skoglund and Jacob M. Enk and Nadin Rohland and Heng Li and Ayça Omrak and Sergey L. Vartanyan and Hendrik N. Poinar and Anders G{\"o}therstr{\"o}m and David Reich and Love Dal{\'e}n}, journal={Current Biology}, year={2015}, volume={25}, pages={1395-1400} }
218 Citations
Million-year-old DNA sheds light on the genomic history of mammoths
- Biology, GeographyNature
- 2021
It is shown that the majority of protein-coding changes associated with cold adaptation in woolly mammoths were already present one million years ago, highlighting the potential of deep-time palaeogenomics to expand the understanding of speciation and long-term adaptive evolution.
Mitogenome evolution in the last surviving woolly mammoth population reveals neutral and functional consequences of small population size
- BiologyEvolution letters
- 2017
The results suggest that isolation on Wrangel Island led to an increase in the frequency of deleterious genetic variation, and thus are consistent with the hypothesis that strong genetic drift in small populations leads to purifying selection being less effective in removing deleteriously mutations.
Full Mitogenomes in the Critically Endangered Kākāpō Reveal Major Post-Glacial and Anthropogenic Effects on Neutral Genetic Diversity
- Biology, Environmental ScienceGenes
- 2018
It is argued that despite high pre-decline genetic diversity, a rapid and range-wide decline combined with the lek mating system, and life-history traits of kākāpō contributed to a rapid loss of genetic diversity following severe population declines.
Functional architecture of deleterious genetic variants in the Wrangel Island mammoth genome
- Biology
- 2018
It is shown that the Wrangel Island mammoth accumulated many putative deleterious mutations that are predicted to cause diverse behavioral and developmental defects, and suggests that WrAngel Island mammoths may have suffered adverse consequences from their reduced population sizes and isolation.
Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth
- BiologyGenome biology and evolution
- 2020
Abstract Woolly mammoths were among the most abundant cold-adapted species during the Pleistocene. Their once-large populations went extinct in two waves, an end-Pleistocene extinction of continental…
Population history of the golden eagle inferred from whole-genome sequencing of three of its subspecies
- Environmental Science, Biology
- 2020
This study reconstructs fluctuations in Ne in three golden eagle subspecies using the pairwise sequential Markovian coalescent (PSMC) model based on whole-genome sequence data and finds evidence for gene flow from continental populations into the ancestral Japanese population resulting in a short, sharp recovery in genetic diversity.
High diversity, inbreeding and a dynamic Pleistocene demographic history revealed by African buffalo genomes
- BiologyScientific reports
- 2021
Genome-wide heterozygosity was the highest for any mammal for which these data are available, while differences in individual inbreeding coefficients reflected the severity of historical bottlenecks and current census sizes in each population.
Accumulation and functional architecture of deleterious genetic variants during the extinction of Wrangel Island Mammoths
- Environmental Science, BiologybioRxiv
- 2017
It is shown that the extinction of Wrangel Island mammoths was accompanied by an accumulation of deleterious mutations that are predicted to cause diverse behavioral and developmental defects, indicating that last mammoths likely suffered from genetic disease that reduced fitness and directly contributed to their extinction.
The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis
- BiologyScientific reports
- 2017
The genetic results and the pattern of morphological variation in time and space suggest that male-mediated gene flow, rather than large-scale dispersals, was important in the Pleistocene evolutionary history of mammoths.
Complete genomes of two extinct New Zealand passerines show responses to climate fluctuations but no evidence for genomic erosion prior to extinction
- BiologyBiology Letters
- 2019
Human intervention, pre-human climate change (or a combination of both), as well as genetic effects, contribute to species extinctions. While many species from oceanic islands have gone extinct due…
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