Complete Genome Sequence of K14JB01, a Novel Variant Strain of Porcine Epidemic Diarrhea Virus in South Korea

  title={Complete Genome Sequence of K14JB01, a Novel Variant Strain of Porcine Epidemic Diarrhea Virus in South Korea},
  author={Yoon-young Cho and Seong-in Lim and Yong Kwan Kim and Jae-Young Song and Joong-Bok Lee and Dong-Jun An},
  journal={Genome Announcements},
ABSTRACT A novel variant strain of porcine epidemic diarrhea virus (PEDV) emerged on pig farms in South Korea during late 2013. Genomic DNA isolated from a K14JB01 strain identified in a diarrheal pig showed high sequence similarity to PEDV strains prevailing in the United States in 2013. This is the first study to identify the complete genome sequence of a novel variant PEDV in South Korea. 

Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine Epidemic Diarrhoea Virus in Taiwan

The high similarity of the S protein among the Taiwan and the globally emerged non‐S INDEL PEDV strains suggests that the Taiwan new variants may share similar pathogenesis and immunogenicity as the global outbreak variants.

Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus samples obtained from farms in Gansu, China.

Sequence analysis of the spike protein (S) genes showed that each specimen had unique characteristics, and that the PEDV1/S/4 strain could be differentiated from the others via a unique mutation of the S gene.

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The phylogenetic tree analysis revealed that the Philippine samples clustered in group 2–1 of the PEDV, wherein the isolates of this group were responsible for the outbreaks in Asia and the USA.

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Epidemic PEDV strains tend to be more pathogenic and cause increased death in pigs, thereby causing substantial financial losses for swine producers, and the need for new vaccines based on the current circulating P EDV is highlighted.

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The results suggested that PRRSV was a risk factor in the outbreak of PED in immunized swine herds and the experimental model was stable and no interference factors affected the results of the study.

PEDV Infection Generates Conformation-Specific Antibodies That Can Be Effectively Detected by a Cell-Based ELISA

It was found that most spike-specific antibodies produced upon PEDV infection in pigs are conformation-specific and they could be detected on S-Bac-infected insect cells by immunofluorescent assay, but they were insensitive to Western blot analysis, the typical method for antiserum analysis.

EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare), 2014. Scientific Opinion on porcine epidemic diarrhoea and emerging pig deltacoronavirus

The clinical signs of PEDV infections in naive pigs are similar in different countries with mortalities up to 100% in naive newborn piglets, but the impact of recently reported PED outbreaks in Asia and the USA seems to be more severe than what has been described in Europe.



Cloning and Sequence Analysis of the M gene of Porcine Epidemic Diarrhea Virus LJB/03

Sequence analysis of the M gene, including genetic distance measurement, phylogenetic tree analysis, and residue substitution analysis, showed that all other PED viruses analyzed fell into three groups, and the LJB/03 itself branched in an independent group.

A new coronavirus-like particle associated with diarrhea in swine

Coronavirus-like particles were detected by electron microscopy in the intestinal contents of pigs during a diarrheal outbreak on 4 swine breeding farms, which was found to be distinct from the known porcine coronaviruses, transmissible gastroenteritis virus and hemagglutinating encephalomyelitis virus.

Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences

  • G. StevensonH. Hoang K. Yoon
  • Biology, Medicine
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2013
The nearly simultaneous outbreaks of disease, and high degree of homology between the PEDV strains from the 4 unrelated farms, suggests a common source of virus.

Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines

The molecular and genetic characteristics of the porcine epidemic diarrhoea virus are described, its molecular epidemiology and diagnosis, what vaccines are available, and how PEDV can be treated are discussed.

Virus-like particles associated with porcine epidemic diarrhoea

Enterotoxigenic Escherichia coli, rotavirus, porcine epidemic diarrhoea virus, adenovirus and calici-like virus in porcine postweaning diarrhoea in Hungary.

It was concluded that K88+ET EC was the overwhelming aetiologic agent of porcine postweaning diarrhoea in Hungary, but F18ac+ETEC, group A rotavirus and PED virus were also significant.

Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy

There was an epidemic of diarrhoea affecting pigs of all ages in Italy between May 2005 and June 2006. In 63 herds the cause was confirmed as porcine epidemic diarrhoea virus by electron microscopy,

Prevalence of porcine epidemic diarrhoea virus and transmissible gastroenteritis virus infection in Korean pigs

This document summarizes current knowledge of Muller's superior tarsal muscle, Horner's syndrome, and related disorders in horses and other animals from the 1980s and 1990s through to the present.

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

ClUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W, providing an integrated system for performing multiple sequence and profile alignments and analysing the results.

Genome Announcements 2 May

  • Genome Announcements 2 May
  • 2014