Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL‐6 production during initiation of the immune response

@inproceedings{Fontes2017CompleteFA,
  title={Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL‐6 production during initiation of the immune response},
  author={Jillian A. Fontes and Jobert G. Barin and Monica Vladut Talor and Natalie R. Stickel and Julie A. Schaub and Noel R. Rose and Daniela {\vC}ih{\'a}kov{\'a}},
  booktitle={Immunity, inflammation and disease},
  year={2017}
}
INTRODUCTION Complete Freund's Adjuvant (CFA) emulsified with an antigen is a widely used method to induce autoimmune disease in animal models, yet the contribution of CFA to the immune response is not well understood. We compared the effectiveness of CFA with Incomplete Freund's Adjuvant (IFA) or TiterMax Gold Adjuvant (TMax) in experimental autoimmune myocarditis (EAM) in male mice. METHODS EAM was induced in A/J, BALB/c, and IL6KO BALB/c male mice by injection of the myocarditogenic… CONTINUE READING
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