Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population

@article{Negur2010CompleteBM,
  title={Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population},
  author={Lucian Negură and Nancy Uhrhammer and Anca Mihaela Negură and Vlad Artenie and Eugen Carasevici and Yves-Jean Bignon},
  journal={Familial Cancer},
  year={2010},
  volume={9},
  pages={519-523}
}
Breast cancer is the most common cancer in women worldwide, including Romania, where its incidence has increased significantly during the last decade. Ovarian cancer is the fourth leading cause of mortality by cancer in women. BRCA1 and BRCA2 are major cancer predisposition genes, responsible for a large percentage of hereditary breast and ovarian cancer (HBOC) families. We investigated 17 patients from unrelated HBOC families in north-eastern Romania, screening for mutations in BRCA1 and BRCA2… CONTINUE READING

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1 Excerpt

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