Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription.

@article{Bushnell2003Complete1R,
  title={Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription.},
  author={David A. Bushnell and Roger D. Kornberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 12},
  pages={6969-73}
}
The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation. 
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Electrophoresis 18, 2714–2723

  • N. Guex, M. C. Peitsch
  • Bushnell and Kornberg PNAS June
  • 1997
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