Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex.

@article{Obrien1996ComplementationMO,
  title={Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex.},
  author={Timothy P O'brien and Danika L. Metallinos and Hong Chen and Mann Kyoon Shin and Shirley M. Tilghman},
  journal={Genetics},
  year={1996},
  volume={143 1},
  pages={447-61}
}
The s15DttMb, s36Pub, s1Acrg and s24Pub piebald deletion alleles belong to a set of overlapping deficiencies on the distal portion of chromosome 14. Molecular analysis was used to define the extent of the deletions. Mice homozygous for the smallest deletion, s15DttMb, die shortly after delivery and display alterations in the central nervous system, including hydrocephalus and a dorsally restricted malformation of the spinal cord. These mice also display homeotic transformations of vertebrae in… CONTINUE READING