Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

@article{Watling1993ComplementationBT,
  title={Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway},
  author={Diane Watling and Dmitry Guschin and Mathias Mueller and Olli Silvennoinen and Bruce A. Witthuhn and Frederick W. Quelle and Neil C. Rogers and Chris Schindler and George R Stark and James N. Ihle and lan M. Kerr},
  journal={Nature},
  year={1993},
  volume={366},
  pages={166-170}
}
INTERFERONS (IFNs) & alpha;/& beta; (type I) and & gamma; (type II) bind to distinct cell surface receptors1, inducing transcription of overlapping sets of genes by intracellular pathways that have recently attracted much attention2,3. Previous studies using cell lines selected for their inability to respond to IFN-& alpha; (ref. 4) have shown that the protein kinase Tyk2 plays a central role in the IFN & alpha;/& beta; response5. Here we report the isolation of the cell… CONTINUE READING
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