Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model.


BACKGROUND Atherothrombosis is a major cause of cardiovascular events. However, animal models to study this process are scarce. OBJECTIVES We describe the first murine model of acute thrombus formation upon plaque rupture to study atherothrombosis by intravital fluorescence microscopy. METHODS Localized rupture of an atherosclerotic plaque in a carotid… (More)
DOI: 10.1111/j.1538-7836.2008.03186.x