Complementary roles of microtubules and microfilaments in the lung fibroblast-mediated contraction of collagen gels: Dynamics and the influence of cell density

@article{Redden2006ComplementaryRO,
  title={Complementary roles of microtubules and microfilaments in the lung fibroblast-mediated contraction of collagen gels: Dynamics and the influence of cell density},
  author={Robert A. Redden and Edward J. Doolin},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2006},
  volume={42},
  pages={70-74}
}
SummaryFibroblasts are important cellular components in wound healing, scar formation, and fibrotic disorders; and the fibroblast-populated collagen-gel (FPCG) model allows examination of fibroblast behavior in an in vitro three-dimensional environment similar to that in vivo. Contraction of free-floating FPCGs depends, on an active and dynamic cytoskeleton, and the contraction dynamics are highly influenced by cell density. We investigated mechanistic differences between high- and low-cell… CONTINUE READING
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