Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.

@article{Guo2003ComplementaryRO,
  title={Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.},
  author={Grace L. Guo and Gilles Lambert and Masahiko Negishi and Jerrold M Ward and Hollis B Brewer and Steven A. Kliewer and Frank J. Gonzalez and Christopher J. Sinal},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={45062-71}
}
The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining bile acid homeostasis. Deletion of both FXR and PXR in vivo by cross-breeding B6;129-Fxrtm1Gonz (FXR-null) and B6;129-Pxrtm1Glaxo-Wellcome (PXR-null) mice revealed a more severe disruption of bile acid, cholesterol, and lipid homeostasis in B6;129-Fxrtm1Gonz Pxrtm1Glaxo-Wellcome (FXR-PXR double null or FPXR-null) mice fed a 1% cholic acid (CA) diet. Hepatic expression of the… CONTINUE READING
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