Complementary microbial approaches for the preparation of optically pure aromatic molecules

@article{Contente2012ComplementaryMA,
  title={Complementary microbial approaches for the preparation of optically pure aromatic molecules},
  author={Martina Letizia Contente and Tiziana Mariarita Granato and William Remelli and Paolo Zambelli and Stefano Raimondi and Maddalena Rossi and Diego Romano},
  journal={Annals of Microbiology},
  year={2012},
  volume={63},
  pages={1021-1027}
}
Different strategies for stereoselective microbial preparation of various chiral aromatic compounds are described. Optically pure 2-methyl-3-phenyl-1-propanol, ethyl 2-methyl-3-phenylpropanoate, 2-methyl-3-phenylpropanal, 2-methyl-3-phenylpropionic acid and 2-methyl-3-phenylpropyl acetate have been prepared using different microbial biotransformations starting from different prochiral and/or racemic substrates. (S)-2-Methyl-3-phenyl-1-propanol and (S)-2-methyl-3-phenylpropanal were prepared by… 
Recombinant S. cerevisiae expressing Old Yellow Enzymes from non-conventional yeasts: an easy system for selective reduction of activated alkenes
TLDR
The OYE biocatalysts, based on recombinant S. cerevisiae expressing OYE genes from non-conventional yeasts, were able to differently reduce the activated double bond of enones, enals and nitro-olefins, exhibiting a wide range of substrate specificity.

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