• Corpus ID: 83977536

Complementary immune roles for infected and uninfected cells during Legionella pneumophila infection

@inproceedings{Copenhaver2015ComplementaryIR,
  title={Complementary immune roles for infected and uninfected cells during Legionella pneumophila infection},
  author={Alan M Copenhaver},
  year={2015}
}
The innate immune system responds to virulent pathogens, yet many pathogens manipulate host-signaling pathways, which should limit immune activation. The intracellular bacterium Legionella pneumophila is the cause of the severe pneumonia Legionnaire's disease. L. pneumophila encodes a type IV secretion system (T4SS) to translocate bacterial proteins into the cytosol of infected host cells. Several of these bacterial effectors (Lgt1, Lgt2, Lgt3, SidI, SidL, Pkn5, and Lpg1489) inactivate host… 

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