Complementary hierarchical clustering.

  title={Complementary hierarchical clustering.},
  author={Gen Nowak and Robert Tibshirani},
  volume={9 3},
When applying hierarchical clustering algorithms to cluster patient samples from microarray data, the clustering patterns generated by most algorithms tend to be dominated by groups of highly differentially expressed genes that have closely related expression patterns. Sometimes, these genes may not be relevant to the biological process under study or their functions may already be known. The problem is that these genes can potentially drown out the effects of other genes that are relevant or… CONTINUE READING


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