Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.

@article{Fribley2011ComplementaryCH,
  title={Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.},
  author={Andrew M. Fribley and Patricia G Cruz and Justin R. Miller and Michael U Callaghan and Peter Cai and Neha Narula and Richard R. Neubig and Hollis D Showalter and Scott D Larsen and Paul D. Kirchhoff and Martha J. Larsen and Douglas A. Burr and Pamela J. Schultz and Renju R Jacobs and Giselle Tamayo-Castillo and David Ron and David H. Sherman and Randal J Kaufman},
  journal={Journal of biomolecular screening},
  year={2011},
  volume={16 8},
  pages={825-35}
}
Despite advances toward understanding the prevention and treatment of many cancers, patients who suffer from oral squamous cell carcinoma (OSCC) confront a survival rate that has remained unimproved for more than 2 decades, indicating our ability to treat them pharmacologically has reached a plateau. In an ongoing effort to improve the clinical outlook for this disease, we previously reported that an essential component of the mechanism by which the proteasome inhibitor bortezomib (PS-341… CONTINUE READING