Complementary addressed modification and cleavage of a single stranded DNA fragment with alkylating oligonucleotide derivatives.

Abstract

A single stranded DNA fragment was modified with alkylating derivatives of oligonucleotides complementary to a certain nucleotide sequences in the fragment. The derivatives carried aromatic 2-chloroethylamino groups at their 3'- or 5'-terminal nucleotide residues. Some of the derivatives carried both alkylating group and intercalating phenazine group which… (More)

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