Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.

  title={Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.},
  author={Hiroya Hashizume and Beverly L. Falc{\'o}n and T. Kuroda and Peter Baluk and Angela Coxon and Dongyin Yu and James V. Bready and Jonathan D. Oliner and D M Mcdonald},
  journal={Cancer research},
  volume={70 6},
Inhibition of angiopoietin-2 (Ang2) can slow tumor growth, but the underlying mechanism is not fully understood. Because Ang2 is expressed in growing blood vessels and promotes angiogenesis driven by vascular endothelial growth factor (VEGF), we asked whether the antitumor effect of Ang2 inhibition results from reduced sprouting angiogenesis and whether the effect is augmented by inhibition of VEGF from tumor cells. Using Colo205 human colon carcinomas in nude mice as a model, we found that… CONTINUE READING


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Aberrant activation of the androgen receptor by NF - κ B 2 / p 52 in prostate cancer cells

  • N Nadiminty, W Lou, +6 authors AC Gao
  • Cancer Res
  • 2010

Anti-PlGF inhibits growth of Cancer Research h

  • C Fischer, B Jonckx, M Mazzone
  • 2010
1 Excerpt

Molecular mechanism of chemoresistance by astrocyte elevated gene - 1

  • ZH Lu, MB Shvartsman, +8 authors JM Arbeit
  • Cancer Res
  • 2010

Oncogenic role of miR - 483 - 3 p at the IGF 2 / 483 locus

  • W Lu, G Zhang, +4 authors C Li
  • Cancer Res
  • 2010

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