Complementary Therapies for Neuropathic and Neuralgic Pain: Systematic Review

  title={Complementary Therapies for Neuropathic and Neuralgic Pain: Systematic Review},
  author={Max H. Pittler and Edzard Ernst},
  journal={The Clinical Journal of Pain},
  • M. PittlerE. Ernst
  • Published 1 October 2008
  • Medicine, Psychology
  • The Clinical Journal of Pain
ObjectiveTo assess the evidence from rigorous clinical trials, systematic reviews, and meta-analyses of complementary and alternative therapies for treating neuropathic and neuralgic pain. MethodsSystematic searches were carried out in the databases Medline, Embase, Amed, Scopus, the Cochrane Database of Systematic Reviews, Natural Standard, and the Natural Medicines Comprehensive Database. Each database was searched from its respective inception until March 2006. To be included, trials were… 

Acupuncture for neuropathic pain in adults.

Six randomised controlled trials with treatment duration of eight weeks or longer comparing acupuncture with sham acupuncture, other active therapies, or treatment as usual, for neuropathic pain in adults found evidence was not available for pain intensity, pain relief, adverse events or any of the other secondary outcomes.

Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

A systematic review and meta-analysis of all randomized controlled trials of Cannabis-based medicines suggests that CBMs might be effective for chronic pain treatment, based on limited evidence, primarily for neuropathic pain patients.

Complementary and alternative medicine in chronic neurological pain

There is little evidence for the most beneficial CAM remedies that target common neurological disorders, and further scientific data from evidence-based studies is needed to accurately compare the CAM therapies amongst each other and allopathic treatments.

Outcome Measures in Randomized-controlled Trials of Neuropathic Pain Conditions: A Systematic Review of Systematic Reviews and Recommendations for Practice

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Interventions for treating pain and disability in adults with complex regional pain syndrome.

There is a critical lack of high quality evidence for the effectiveness of most therapies for CRPS, and low quality evidence suggests that physiotherapy or occupational therapy are associated with small positive effects that are unlikely to be clinically important at one year follow up when compared with a social work passive attention control.

The Immediate Analgesic Effect of Acupuncture for Pain: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis of randomized controlled trials on disease-related pain to critically evaluate the immediate effect of acupuncture for pain relief found acupuncture was associated with a greater immediate pain relief effect compared to sham acupuncture and analgesic injections.

Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.

There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.

Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The current evidence suggests that ALC has a moderate effect in reducing pain measured on VAS in PNP patients with acceptable safety and larger trials with longer follow-up are warranted to establish the effects.



Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

Cannabinoids are no more effective than codeine in controlling pain and have depressant effects on the central nervous system that limit their use, and in acute postoperative pain they should not be used.

Analgesic Therapy in Postherpetic Neuralgia: A Quantitative Systematic Review

The evidence base supports the oral use of tricyclic antidepressants, certain opioids, and gabapentinoids in PHN, and a single study of spinal intrathecal administration of lidocaine and methylprednisolone demonstrated efficacy, although this has yet to be replicated.

Systematic review of topical capsaicin for the treatment of chronic pain

Although topically applied capsaicin has moderate to poor efficacy in the treatment of chronic musculoskeletal or neuropathic pain, it may be useful as an adjunct or sole therapy for a small number of patients who are unresponsive to, or intolerant of, other treatments.

The use of complementary and alternative medicines by patients with peripheral neuropathy

A critical review of randomized controlled trials of static magnets for pain relief.

  • N. Eccles
  • Medicine
    Journal of alternative and complementary medicine
  • 2005
The weight of evidence from published, well-conducted controlled trials suggests that static magnetic fields are able to induce analgesia.

Location bias in controlled clinical trials of complementary/alternative therapies.

More positive than negative trials of complementary therapies are published, except in high-impact factor MM-journals, and location of trials in terms of journal type and impact factor should be taken into account when the literature on complementary therapies is being examined.

The Use of Complementary and Alternative Medicine for Pain

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St. John's wort has no effect on pain in polyneuropathy