Complementary Sequence-Mediated Exon Circularization

  title={Complementary Sequence-Mediated Exon Circularization},
  author={Xiao-Ou Zhang and Haibin Wang and Yang Zhang and Xuhua Lu and Ling-Ling Chen and Li Yang},
Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences. Such sequences and their distribution exhibit rapid evolutionary changes, showing that exon circularization is evolutionarily dynamic. Strikingly, exon circularization efficiency can be regulated by… CONTINUE READING
Highly Influential
This paper has highly influenced 31 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 212 extracted citations


Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…