Complementary Sequence-Mediated Exon Circularization

@article{Zhang2014ComplementarySE,
  title={Complementary Sequence-Mediated Exon Circularization},
  author={Xiao-Ou Zhang and Haibin Wang and Yang Zhang and Xuhua Lu and Ling-Ling Chen and Li Yang},
  journal={Cell},
  year={2014},
  volume={159},
  pages={134-147}
}
Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences. Such sequences and their distribution exhibit rapid evolutionary changes, showing that exon circularization is evolutionarily dynamic. Strikingly, exon circularization efficiency can be regulated by… CONTINUE READING
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