Complementary Effects of Two Growth Factors in Multifunctionalized Silk Nanofibers for Nerve Reconstruction

@inproceedings{Dinis2014ComplementaryEO,
  title={Complementary Effects of Two Growth Factors in Multifunctionalized Silk Nanofibers for Nerve Reconstruction},
  author={Tony M. Dinis and Guillaume Vidal and Rodrigo R. Jose and Pascale Vigneron and Damien Bresson and Vincent Fitzpatrick and Fr{\'e}d{\'e}ric Marin and David L Kaplan and Christophe Egles and Thomas Claudepierre},
  booktitle={PloS one},
  year={2014}
}
With the aim of forming bioactive guides for peripheral nerve regeneration, silk fibroin was electrospun to obtain aligned nanofibers. These fibers were functionalized by incorporating Nerve Growth Factor (NGF) and Ciliary NeuroTrophic Factor (CNTF) during electrospinning. PC12 cells grown on the fibers confirmed the bioavailability and bioactivity of the… CONTINUE READING